Acoustofluidic bioassembly induced morphogenesis for therapeutic tissue fabrication

Byungjun Kang, Eunseon Jeong, Seung Yeop Han, Jeong Hyun Heo, Yunam Lee, Suah Choi, Yunjung Choi, Donyoung Kang, Youn-Hoo Hwang, Jiin Lee, Jung Hwa Seo, Jinyoung Kim, Inhea Jeong, Enji Kim, Juyoung Lee, Dae-Eun Kim, Jang-Ung Park, Sung-Rae Cho, Yoonhee Jin, Seung-Woo Cho () and Hyungsuk Lee ()
Additional contact information
Byungjun Kang: Yonsei University
Eunseon Jeong: Yonsei University
Seung Yeop Han: Yonsei University
Jeong Hyun Heo: Yonsei University College of Medicine
Yunam Lee: Yonsei University
Suah Choi: Yonsei University
Yunjung Choi: Yonsei University
Donyoung Kang: Yonsei University
Youn-Hoo Hwang: Yonsei University
Jiin Lee: Yonsei University
Jung Hwa Seo: Yonsei University College of Medicine
Jinyoung Kim: Yonsei University College of Medicine
Inhea Jeong: Yonsei University
Enji Kim: Yonsei University
Juyoung Lee: Yonsei University
Dae-Eun Kim: Yonsei University
Jang-Ung Park: Yonsei University
Sung-Rae Cho: Yonsei University College of Medicine
Yoonhee Jin: Yonsei University College of Medicine
Seung-Woo Cho: Yonsei University
Hyungsuk Lee: Yonsei University

Nature Communications, 2025, vol. 16, issue 1, 1-19

Abstract: Abstract To build in vitro tissues for therapeutic applications, it is essential to replicate the spatial distribution of cells that occurs during morphogenesis in vivo. However, it remains technically challenging to simultaneously regulate the geometric alignment and aggregation of cells during tissue fabrication. Here, we introduce the acoustofluidic bioassembly induced morphogenesis, which is the combination of precise arrangement of cells by the mechanical forces produced by acoustofluidic cues, and the morphological and functional changes of cells in the following in vitro and in vivo cultures. The acoustofluidic bioassembly can be used to create tissues with regulated nano-, micro-, and macro-structures. We demonstrate that the neuromuscular tissue fabricated with the acoustofluidic bioassembly exhibits enhanced contraction dynamics, electrophysiology, and therapeutic efficacy. The potential of the acoustofluidic bioassembly as an in situ application is demonstrated by fabricating artificial tissues at the defect sites of living tissues. The acoustofluidic bioassembly induced morphogenesis can provide a pioneering platform to fabricate tissues for biomedical applications.

Date: 2025
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DOI: 10.1038/s41467-025-59026-4

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