Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis

Abi G. Yates, Annie Khamhoung, Lena Gaebel, Walter Jacob, Daniel E. Radford-Smith, Máté G. Kiss, Pacific Huynh, Teresa Gerhardt, Merlin Heiser, Oren Cohen, Filip K. Swirski, Daniel C. Anthony, James Sumowski, Ilana Katz Sand and Cameron S. McAlpine ()
Additional contact information
Abi G. Yates: Icahn School of Medicine at Mount Sinai
Annie Khamhoung: Icahn School of Medicine at Mount Sinai
Lena Gaebel: Icahn School of Medicine at Mount Sinai
Walter Jacob: Icahn School of Medicine at Mount Sinai
Daniel E. Radford-Smith: University of Oxford
Máté G. Kiss: Icahn School of Medicine at Mount Sinai
Pacific Huynh: Icahn School of Medicine at Mount Sinai
Teresa Gerhardt: Icahn School of Medicine at Mount Sinai
Merlin Heiser: Icahn School of Medicine at Mount Sinai
Oren Cohen: Icahn School of Medicine at Mount Sinai
Filip K. Swirski: Icahn School of Medicine at Mount Sinai
Daniel C. Anthony: University of Oxford
James Sumowski: Icahn School of Medicine at Mount Sinai
Ilana Katz Sand: Icahn School of Medicine at Mount Sinai
Cameron S. McAlpine: Icahn School of Medicine at Mount Sinai

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract Monocytes and neutrophils from the myeloid lineage contribute to multiple sclerosis (MS), but the dynamics of myelopoiesis during MS are unclear. Here we uncover a disease stage-specific relationship between lifestyle, myelopoiesis and neuroinflammation. In mice with relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE), myelopoiesis in the femur, vertebrae and spleen is elevated prior to disease onset and during remission, preceding the peaks of clinical disability and neuroinflammation. In progressive EAE (P-EAE), vertebral myelopoiesis rises steadily throughout disease, while femur and splenic myelopoiesis is elevated early before waning later during disease height. In parallel, sleep disruption or hyperlipidemia and cardiometabolic syndrome augment M-CSF generation and multi-organ myelopoiesis to worsen P-EAE clinical symptoms, neuroinflammation, and spinal cord demyelination, with M-CSF blockade abrogating these symptoms. Lastly, results from a previous trial show that Mediterranean diet restrains myelopoietic activity and myeloid lineage progenitor skewing and improves clinical symptomology of MS. Together, our data suggest that myelopoiesis in MS is dynamic and dependent on disease stage and location, and that lifestyle factors modulate disease by influencing M-CSF-mediated myelopoiesis.

Date: 2025
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DOI: 10.1038/s41467-025-59074-w

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