Epithelial cell competition is promoted by signaling from immune cells

Yilun Zhu, Zeba Wunderlich and Arthur D. Lander ()
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Yilun Zhu: University of California, Irvine
Zeba Wunderlich: Boston University
Arthur D. Lander: University of California, Irvine

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract In epithelial tissues, juxtaposition of cells of different phenotypes can trigger cell competition, a process whereby one type of cell drives death and extrusion of another. During growth and homeostasis, cell competition is thought to serve a quality control function, eliminating cells that are “less fit”. Tissues may also attack and eliminate newly arising tumor cells, exploiting mechanisms shared with other instances of cell competition, but that differ, reportedly, in the involvement of the immune system. Whereas immune cells have been shown to play a direct role in killing tumor cells, this has not been observed in other cases of cell competition, suggesting that tissues recognize and handle cancer cells differently. Here, we challenge this view, showing that, in the fruit fly Drosophila, innate immune cells play similar roles in cell killing during classical cell competition as in eliminating tumors. These findings suggest that immune suppression of cancer may exploit the same mechanisms as are involved in promoting phenotypic uniformity among epithelial cells.

Date: 2025
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DOI: 10.1038/s41467-025-59130-5

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