Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish

Qiaohong Lin, Xian Du, Fan Ren, Ying Liu, Gaorui Gong, Si Ge, Weiwei Li, Zhi Li, Li Zhou, Ming Duan, Xi-Yin Li, Guang-Zhong Wang, Rui Xiao (), Jian-Fang Gui () and Jie Mei ()
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Qiaohong Lin: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Xian Du: Wuhan University
Fan Ren: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Ying Liu: Huazhong Agricultural University
Gaorui Gong: Huazhong Agricultural University
Si Ge: Huazhong Agricultural University
Weiwei Li: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Zhi Li: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Li Zhou: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Ming Duan: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Xi-Yin Li: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Guang-Zhong Wang: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Rui Xiao: Wuhan University
Jian-Fang Gui: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
Jie Mei: University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences

Nature Communications, 2025, vol. 16, issue 1, 1-19

Abstract: Abstract Circadian clocks temporally orchestrate the behavioural and physiological rhythms. The core molecules establishing the circadian clock are clear; however, the critical signalling pathways that cause or favour the homeostasis are poorly understood. Here, we report that anti-Müllerian hormone (Amh)-mediated signalling plays an important role in sustaining circadian homeostasis in zebrafish. Notably, amh knockout dampens molecular clock oscillations and disrupts both behavioural and hormonal circadian rhythms, which are recapitulated in bmpr2a null mutants. Somatotropes and gonadotropes are identified as Amh-targeted pituitary cell populations. Single-cell transcriptome analysis further reveals a lineage-specific regulation of pituitary clock by Amh. Moreover, Amh-induced effect on clock gene expression can be abolished by blocking Smad1/5/9 phosphorylation and bmpr2a knockout. Mechanistically, Amh binds to its receptors, Bmpr2a/Bmpr1bb, which in turn activate Smad1/5/9 by phosphorylation and promote circadian gene expression. Our findings reveal a key hormone signalling pathway for circadian homeostasis in zebrafish with implications for rhythmic organ functions and circadian health.

Date: 2025
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DOI: 10.1038/s41467-025-59528-1

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