The immune NIK1/RPL10/LIMYB signaling module regulates photosynthesis and translation under biotic and abiotic stresses

Marco Aurélio Ferreira (), Ruan M. Teixeira, Otávio J. B. Brustolini, Thainá F. F. Saia, James Jean-Baptiste, Nathalia G. A. Ribeiro, Sâmera S. Breves, Fellipe R. Sampaio, Eulálio G. D. Santos, Borys A. Leon, Celio C. Oliveira, Christiane E. M. Duarte, Lucas L. Lima, Leandro L. Oliveira, Humberto J. O. Ramos, Pedro A. B. Reis and Elizabeth P. B. Fontes ()
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Marco Aurélio Ferreira: Universidade Federal de Viçosa
Ruan M. Teixeira: Universidade Federal de Viçosa
Otávio J. B. Brustolini: Universidade Federal de Viçosa
Thainá F. F. Saia: Universidade Federal de Viçosa
James Jean-Baptiste: Universidade Federal de Viçosa
Nathalia G. A. Ribeiro: Universidade Federal de Viçosa
Sâmera S. Breves: Universidade Federal de Viçosa
Fellipe R. Sampaio: Universidade Federal de Viçosa
Eulálio G. D. Santos: Universidade Federal de Viçosa
Borys A. Leon: Universidade Federal de Viçosa
Celio C. Oliveira: Brazilian Center for Research in Energy and Materials (CNPEM)
Christiane E. M. Duarte: Universidade Federal de Viçosa
Lucas L. Lima: Universidade Federal de Viçosa
Leandro L. Oliveira: Universidade Federal de Viçosa
Humberto J. O. Ramos: Universidade Federal de Viçosa
Pedro A. B. Reis: Universidade Federal de Viçosa
Elizabeth P. B. Fontes: Universidade Federal de Viçosa

Nature Communications, 2025, vol. 16, issue 1, 1-19

Abstract: Abstract Photosynthesis and translation are targets of metabolic control and development in plants, yet how stress signals coordinately regulate these opposing energy-producing and consuming processes remains enigmatic. Here, we unravel a growth control circuit that ties photosynthesis to translational control in response to biotic and abiotic signals. Our findings reveal that the L10-INTERACTING MYB DOMAIN-CONTAINING PROTEIN (LIMYB), a key player of the NUCLEAR SHUTTLE PROTEIN-INTERACTING KINASE 1 (NIK1)/ RIBOSOMAL PROTEIN L10 (RPL10) antiviral signaling pathway, not only downregulates translation genes, but also represses photosynthesis-related genes and photosynthesis itself. LIMYB repressor activity, regulated by phosphorylation, is crucial for the decline in photosynthesis under stress. NIK1 activation by PAMPs or the phosphomimetic NIK1-T474D represses photosynthesis-related genes and photosynthesis in control but not in limyb lines. Furthermore, heat and osmotic stress also activate the NIK1/RPL10/LIMYB signaling circuit in wild type. These stresses induce NIK1 phosphorylation, but not marker gene repression, in limyb, indicating that LIMYB connects NIK1 activation to stress-mediated downregulation of translation- and photosynthesis-related genes. This coordinated repression via the NIK1/RPL10/LIMYB module may help plants adapt to changing environments.

Date: 2025
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DOI: 10.1038/s41467-025-59571-y

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