Mapping pesticide-induced metabolic alterations in human gut bacteria

Li Chen, Hong Yan, Shanshan Di, Chao Guo, Huan Zhang, Shiqi Zhang, Andrew Gold, Yu Wang, Ming Hu, Dayong Wu, Caroline H. Johnson, Xinquan Wang and Jiangjiang Zhu ()
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Li Chen: The Ohio State University
Hong Yan: Yale School of Public Health
Shanshan Di: Zhejiang Academy of Agricultural Sciences
Chao Guo: The Ohio State University
Huan Zhang: The Ohio State University
Shiqi Zhang: The Ohio State University
Andrew Gold: The Ohio State University
Yu Wang: Johns Hopkins University School of Medicine
Ming Hu: The Ohio State University
Dayong Wu: The Ohio State University College of Medicine
Caroline H. Johnson: Yale School of Public Health
Xinquan Wang: Zhejiang Academy of Agricultural Sciences
Jiangjiang Zhu: The Ohio State University

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract Pesticides can modulate gut microbiota composition, but their specific effects on it remain largely elusive. In our study, we show that pesticides inhibit or promote the growth of various gut microbial species and can be accumulated to prolong their presence in the host. Pesticide exposure also induces significant alterations in gut bacterial metabolism, as reflected by changes in hundreds of metabolites. We generate a pesticide-gut microbiota-metabolite network that not only reveals pesticide-sensitive gut bacteria species but also reports specific metabolic changes in 306 pesticide-gut microbiota pairs. Using an in vivo mouse model, we further demonstrate the interactions of a representative pesticide-gut microbiota pair and verify the inflammation-inducing effects of pesticide exposure on the host, mediated by microbially dysregulated lipid metabolism. Taken together, our findings generate a comprehensive atlas of pesticide-gut microbiota-metabolite interactions atlas and shed light on the molecular mechanisms by which pesticides affect host health via gut microbiota-modulated metabolism.

Date: 2025
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DOI: 10.1038/s41467-025-59747-6

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