Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study

Richard Dumbill (), Simon Knight, James Hunter, John Fallon, Daniel Voyce, Jacob Barrett, Matt Ellen, Elizabeth Conroy, Ian SD Roberts, Tim James, Gabrielle Allen, Jennifer Brook, Annemarie Weissenbacher, Rutger Ploeg, Constantin Coussios () and Peter Friend
Additional contact information
Richard Dumbill: University of Oxford
Simon Knight: University of Oxford
James Hunter: University of Oxford
John Fallon: University of Oxford
Daniel Voyce: OrganOx Ltd
Jacob Barrett: OrganOx Ltd
Matt Ellen: OrganOx Ltd
Elizabeth Conroy: University of Oxford
Ian SD Roberts: Oxford University Hospitals NHS Foundation Trust
Tim James: Oxford University Hospitals NHS Foundation Trust
Gabrielle Allen: Oxford University Hospitals NHS Foundation Trust
Jennifer Brook: Oxford University Hospitals NHS Foundation Trust
Annemarie Weissenbacher: Medical University of Innsbruck
Rutger Ploeg: University of Oxford
Constantin Coussios: OrganOx Ltd
Peter Friend: University of Oxford

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract Kidney transplantation is the preferred treatment for end-stage renal disease and is limited by donor organ availability. Normothermic Machine Perfusion (NMP) might facilitate safe transplantation of marginal organs. NKP1 is a single centre, phase 1, 36-patient, three-stage cohort study investigating the safety and feasibility of up to 24 hours of renal NMP prior to transplantation. 30-day graft survival (primary endpoint) was 100%. Secondary objectives were assessment of the effect of NMP on post-transplant clinical outcomes and ischaemia-reperfusion injury, identification of predictive biomarkers, and characterisation of the performance of the preservation system. Clinical outcomes were comparable to a matched control cohort with 12-month estimated glomerular filtration rate (eGFR) 46.3 vs 49.5 mL/min/1.73m2 (p = 0.44) despite much longer total preservation times (15.7 vs 8.9 hours controls, p

Date: 2025
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DOI: 10.1038/s41467-025-59829-5

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