Bioresorbable, wireless dual stimulator for peripheral nerve regeneration

Hak-Young Ahn, Jordan B. Walters, Raudel Avila, Seyong Oh, Seung Gi Seo, Jong Uk Kim, Jihun Park, Seonggwang Yoo, Yeon Sik Choi, Tae Yeon Kim, Jiaqi Liu, Jae-Young Yoo, Oliver Ralph Weissleder, Dominic D’Andrea, Chanho Park, Geumbee Lee, Donghwi Cho, Woo-Youl Maeng, Hong-Joon Yoon, Grace Wickerson, Yasmine Bouricha, Jing Tian, Tzu Chun Chung, Sumanas W. Jordan, Song Li, Yonggang Huang, Colin K. Franz () and John A. Rogers ()
Additional contact information
Hak-Young Ahn: Northwestern University
Jordan B. Walters: Shirley Ryan AbilityLab
Raudel Avila: Rice University
Seyong Oh: Hanyang University ERICA
Seung Gi Seo: Northwestern University
Jong Uk Kim: Northwestern University
Jihun Park: Northwestern University
Seonggwang Yoo: Northwestern University
Yeon Sik Choi: Yonsei University
Tae Yeon Kim: Northwestern University
Jiaqi Liu: Northwestern University
Jae-Young Yoo: Sungkyunkwan University
Oliver Ralph Weissleder: Northwestern University
Dominic D’Andrea: Shirley Ryan AbilityLab
Chanho Park: Northwestern University
Geumbee Lee: Kyungpook National University
Donghwi Cho: Korea Research Institute of Chemical Technology
Woo-Youl Maeng: Northwestern University
Hong-Joon Yoon: Gachon University
Grace Wickerson: Northwestern University
Yasmine Bouricha: Shirley Ryan AbilityLab
Jing Tian: University of California Los Angeles
Tzu Chun Chung: University of California Los Angeles
Sumanas W. Jordan: Northwestern University
Song Li: University of California Los Angeles
Yonggang Huang: Northwestern University
Colin K. Franz: Northwestern University
John A. Rogers: Northwestern University

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract Wireless bioresorbable electrical stimulators have broad potential as therapeutic implants. Such devices operate for a clinically relevant duration and then harmlessly dissolve, eliminating the need for surgical removal. A representative application is in treating peripheral nerve injuries through targeted stimulation at either proximal or distal sites, with operation for up to one week. This report introduces enhanced devices with additional capabilities: (1) simultaneous stimulation of both proximal and distal sites, and (2) robust operation for as long as several months, all achieved with materials that naturally resorb by hydrolysis in surrounding biofluids. Systematic investigations of the materials and design aspects highlight the key features that enable dual stimulation and with enhanced stability. Animal model studies illustrate beneficial effects in promoting peripheral nerve regeneration, as quantified by increased total muscle and muscle fiber cross-sectional area and compound muscle action potentials. These findings expand the clinical applications of bioresorbable stimulators, particularly for long-term nerve regeneration and continuous neuromodulation-based monitoring.

Date: 2025
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DOI: 10.1038/s41467-025-59835-7

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