Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk
Filippos Anagnostakis,
Sarah Ko,
Mehrshad Saadatinia,
Jingyue Wang,
Christos Davatzikos and
Junhao Wen ()
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Filippos Anagnostakis: Columbia University
Sarah Ko: Columbia University
Mehrshad Saadatinia: Columbia University
Jingyue Wang: Columbia University
Christos Davatzikos: University of Pennsylvania
Junhao Wen: Columbia University
Nature Communications, 2025, vol. 16, issue 1, 1-14
Abstract:
Abstract Multi-organ biological aging clocks across different organ systems have been shown to predict human disease and mortality. Here, we extend this multi-organ framework to plasma metabolomics, developing five organ-specific metabolome-based biological age gaps (MetBAGs) using 107 plasma non-derivatized metabolites from 274,247 UK Biobank participants. Our age prediction models achieve a mean absolute error of approximately 6 years (0.25
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-59964-z
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DOI: 10.1038/s41467-025-59964-z
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