Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk

Filippos Anagnostakis, Sarah Ko, Mehrshad Saadatinia, Jingyue Wang, Christos Davatzikos and Junhao Wen ()
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Filippos Anagnostakis: Columbia University
Sarah Ko: Columbia University
Mehrshad Saadatinia: Columbia University
Jingyue Wang: Columbia University
Christos Davatzikos: University of Pennsylvania
Junhao Wen: Columbia University

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract Multi-organ biological aging clocks across different organ systems have been shown to predict human disease and mortality. Here, we extend this multi-organ framework to plasma metabolomics, developing five organ-specific metabolome-based biological age gaps (MetBAGs) using 107 plasma non-derivatized metabolites from 274,247 UK Biobank participants. Our age prediction models achieve a mean absolute error of approximately 6 years (0.25

Date: 2025
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DOI: 10.1038/s41467-025-59964-z

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