Enantioselective electroreductive alkyne-aldehyde coupling

Xiyang Cao, Yuyang Fu, Yongsheng Tao and Qingquan Lu ()
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Xiyang Cao: Wuhan University
Yuyang Fu: Wuhan University
Yongsheng Tao: Wuhan University
Qingquan Lu: Wuhan University

Nature Communications, 2025, vol. 16, issue 1, 1-8

Abstract: Abstract Electrocatalytic methods that facilitate the asymmetric reductive coupling of two π-components with complete control over regio-, stereo-, and enantioselectivity remain underexplored. Herein, we report a highly regio- and enantioselective cobaltaelectro-catalyzed alkyne-aldehyde coupling reaction, in which protons and electrons serve as the hydrogen source and reductant, respectively. Earth-abundant cobalt and air-stable (S,S)−2,3-bis(tert-butylmethylphosphino)quinoxaline (QuinoxP*) are used as the catalyst and ligand, respectively. A series of enantioenriched allylic alcohols can be constructed with excellent regio- (>19:1), stereo- (>19:1 E:Z), and enantioselectivity (up to 98% ee).

Date: 2025
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DOI: 10.1038/s41467-025-60230-5

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