Blood-triggered self-sealing and tissue adhesive hemostatic nanofabric

Yan Fang, Linyu Wang, Xinwei Zheng, Peng Ni, Zhibo Xu, Ziying Wang, Yunxiang Weng, Qinhui Chen () and Haiqing Liu ()
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Yan Fang: Fujian Normal University
Linyu Wang: Fujian Normal University
Xinwei Zheng: Fujian Normal University
Peng Ni: Fujian Normal University
Zhibo Xu: Fujian Normal University
Ziying Wang: Fujian Normal University
Yunxiang Weng: Fujian Normal University
Qinhui Chen: Fujian Normal University
Haiqing Liu: Fujian Normal University

Nature Communications, 2025, vol. 16, issue 1, 1-19

Abstract: Abstract Current hemostatic fabric often encounters the issue of blood seeping or leaking through the fabric and at the junctions between the fabric and tissue, leading to extra blood loss. Herein, we report a hemostatic nanofabric composed of anionic and cationic nanofibers. Upon contact with wound, the porous nanofabric can absorb the interfacial blood and self-seal to form a compact physical barrier through interfiber bonding, preventing blood from longitudinally penetrating the fabric. This process results in the encapsulation of blood components within the electrostatically crosslinked nanofiber network, creating a robust thrombus that reinforces the physical barrier. Moreover, this nanofabric exhibits strong tissue adhesiveness, inhibiting blood seeping out at the seam of the fabric and tissue. Its hemostatic performance in animal injuries surpasses that of standard cotton gauze and Combat GauzeTM. In the pig femoral artery injury, the blood loss from the nanofabric is only ca. 8% of that from Combat GauzeTM. The nanofabric exhibits excellent biodegradability, hemocompatibility, cytocompatibility, antibacterial activity, and wound healing promotion.

Date: 2025
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DOI: 10.1038/s41467-025-60244-z

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