Reduction of neuronal activity mediated by blood-vessel regression in the adult brain

Xiaofei Gao, Xing-jun Chen, Meng Ye, Jun-Liszt Li, Nannan Lu, Di Yao, Bo Ci, Fei Chen, Lijun Zheng, Yating Yi, Shiwen Zhang, Zhanying Bi, Xinwei Gao, Yuanlei Yue, Tingbo Li, Jiafu Lin, Ying-Chao Shi, Kaibin Shi, Nicholas E. Propson, Yubin Huang, Katherine Poinsatte, Zhaohuan Zhang, Dale B. Bosco, Shi-bing Yang, Ralf H. Adams, Volkhard Lindner, Fen Huang, Long-Jun Wu, Hui Zheng, Simon Hippenmeyer, Ann M. Stowe, Bo Peng, Marta Margeta, Qingchun Guo, Xiaoqun Wang, Qiang Liu, Jakob Körbelin, Martin Trepel, Hui Lu, Guoen Cai, Bo O. Zhou, Bo Shen, Ying-mei Lu, Wenzhi Sun, Jie-Min Jia, Feng Han, Hu Zhao, Robert M. Bachoo and Woo-ping Ge ()
Additional contact information
Xiaofei Gao: University of Texas Southwestern Medical Center
Xing-jun Chen: Beijing
Meng Ye: Beijing
Jun-Liszt Li: Beijing
Nannan Lu: University of Texas Southwestern Medical Center
Di Yao: Beijing
Bo Ci: University of Texas Southwestern Medical Center
Fei Chen: University of Texas Southwestern Medical Center
Lijun Zheng: Beijing
Yating Yi: Sichuan University
Shiwen Zhang: Sichuan University
Zhanying Bi: Beijing
Xinwei Gao: Beijing
Yuanlei Yue: the George Washington University
Tingbo Li: Westlake University
Jiafu Lin: Fujian Health College
Ying-Chao Shi: Guangdong Institute of Intelligence Science and Technology
Kaibin Shi: Capital Medical University; Chinese Institutes for Medical Research
Nicholas E. Propson: Baylor College of Medicine
Yubin Huang: Chinese Academy of Sciences
Katherine Poinsatte: University of Texas Southwestern Medical Center
Zhaohuan Zhang: University of Texas Southwestern Medical Center
Dale B. Bosco: Mayo Clinic
Shi-bing Yang: University of California at San Francisco
Ralf H. Adams: D-
Volkhard Lindner: MaineHealth Institute for Research
Fen Huang: University of California at San Francisco
Long-Jun Wu: Mayo Clinic
Hui Zheng: Baylor College of Medicine
Simon Hippenmeyer: Am Campus 1
Ann M. Stowe: University of Texas Southwestern Medical Center
Bo Peng: Fudan University
Marta Margeta: University of California at San Francisco
Qingchun Guo: Beijing
Xiaoqun Wang: Changping Laboratory
Qiang Liu: Tianjin Medical University General Hospital
Jakob Körbelin: University Medical Center Hamburg-Eppendorf
Martin Trepel: University Medical Center and Medical Faculty Augsburg University
Hui Lu: the George Washington University
Guoen Cai: Fujian Health College
Bo O. Zhou: Chinese Academy of Sciences; University of Chinese Academy of Sciences
Bo Shen: Beijing (NIBS)
Ying-mei Lu: Nanjing Medical University
Wenzhi Sun: Beijing
Jie-Min Jia: Westlake University
Feng Han: Nanjing Medical University
Hu Zhao: Beijing
Robert M. Bachoo: University of Texas Southwestern Medical Center
Woo-ping Ge: Beijing

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract The brain vasculature supplies neurons with glucose and oxygen, but little is known about how vascular plasticity contributes to brain function. Using longitudinal in vivo imaging, we report that a substantial proportion of blood vessels in the adult mouse brain sporadically occlude and regress. Their regression proceeds through sequential stages of blood-flow occlusion, endothelial cell collapse, relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels are found to be widespread in mouse, monkey and human brains. We further reveal that blood vessel regression cause a reduction of neuronal activity due to a dysfunction in mitochondrial metabolism and glutamate production. Our results elucidate the mechanism of vessel regression and its role in neuronal function in the adult brain.

Date: 2025
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DOI: 10.1038/s41467-025-60308-0

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