Cytoreductive surgery and hyperthermic intrathoracic chemotherapy in thymic epithelial tumors with pleural spread or recurrence: a prospective, single-arm, phase II study

Shuai Wang, Xinyu Yang, Jiahao Jiang, Fei Liang, Yuansheng Zheng, Yongqiang Ao, Jian Gao, Hao Wang, Lijie Tan () and Jianyong Ding ()
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Shuai Wang: Fudan University
Xinyu Yang: Fudan University
Jiahao Jiang: Fudan University
Fei Liang: Fudan University
Yuansheng Zheng: Fudan University
Yongqiang Ao: Fudan University
Jian Gao: Fudan University
Hao Wang: Fudan University
Lijie Tan: Fudan University
Jianyong Ding: Fudan University

Nature Communications, 2025, vol. 16, issue 1, 1-9

Abstract: Abstract Pleural spread or recurrence of thymic epithelial tumors (TETs) is a tricky puzzle in the clinic and there is currently no recognized effective treatment. This trial evaluated the safety and efficacy of cytoreductive surgery and hyperthermic intrathoracic chemotherapy (S-HITOC) for TETs with pleural spread or recurrence. Here, we reported short-term outcomes of enrolled 45 patients receiving S-HITOC with 25 mg/m2 doxorubicin and 50 mg/m2 cisplatin. The pleural tumor index (PTI) has been proposed for evaluating pleural tumor burden. Treatment-related adverse events of grade ≥3 occurred in eight (17.8%) patients. The pain Visual analog scale (VAS) score was 5.4 ± 1.9 on the 1st day after treatment and was similar to that at baseline level on the 7th day after treatment (p = 0.218). There was no significant difference in the quality of life score (p = 0.676) between baseline and the 60th day after treatment. The estimated 2-year PFS and OS rates were 82.8% and 100.0%, respectively. Subgroup analyses revealed that patients with PTI scores >10 had worse PFS than those with PTI scores ≤10 (p

Date: 2025
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DOI: 10.1038/s41467-025-60386-0

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