IvoryOS: an interoperable web interface for orchestrating Python-based self-driving laboratories

Wenyu Zhang (), Lucy Hao, Veronica Lai, Ryan Corkery, Jacob Jessiman, Jiayu Zhang, Junliang Liu, Yusuke Sato, Maria Politi, Matthew E. Reish, Rebekah Greenwood, Noah Depner, Jiyoon Min, Rama El-khawaldeh, Paloma Prieto, Ekaterina Trushina and Jason E. Hein ()
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Wenyu Zhang: The University of British Columbia
Lucy Hao: The University of British Columbia
Veronica Lai: Telescope Innovations Corp
Ryan Corkery: Telescope Innovations Corp
Jacob Jessiman: The University of British Columbia
Jiayu Zhang: The University of British Columbia
Junliang Liu: Telescope Innovations Corp
Yusuke Sato: Telescope Innovations Corp
Maria Politi: The University of British Columbia
Matthew E. Reish: The University of British Columbia
Rebekah Greenwood: The University of British Columbia
Noah Depner: The University of British Columbia
Jiyoon Min: The University of British Columbia
Rama El-khawaldeh: The University of British Columbia
Paloma Prieto: The University of British Columbia
Ekaterina Trushina: The University of British Columbia
Jason E. Hein: The University of British Columbia

Nature Communications, 2025, vol. 16, issue 1, 1-8

Abstract: Abstract Self-driving laboratories (SDLs), powered by robotics, automation and artificial intelligence, accelerate scientific discoveries through autonomous experimentation. However, their adoption and transferability are limited by the lack of standardized software across diverse SDLs. In this work, we introduce IvoryOS – an open-source orchestrator that automatically generates web interfaces for Python-based SDLs. It ensures interoperability by dynamically updating the user interfaces with the plugged components and their functionalities. The interfaces enable users to directly control SDLs and design workflows through a drag-and-drop user interface. Additionally, the workflow manager provides no-code configuration for iterative execution, supporting both human-in-the-loop and closed-loop experimentation. We demonstrate the integration of IvoryOS with six SDLs across two institutes, showcasing its adaptability and utility across platforms at various development stages. The plug-and-play and low-code feature of IvoryOS addresses the rapidly evolving demands of SDL development and significantly lowers the barrier to entry for building and managing SDLs.

Date: 2025
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DOI: 10.1038/s41467-025-60514-w

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