Brain-wide input-output analysis of tuberal nucleus somatostatin neurons reveals hierarchical circuits for orchestrating feeding behavior
Esra Senol,
Menghan Wang,
Yongjuan Xin,
Zhuolei Jiao,
Hasan Mohammad,
Xin Yi Yeo,
Tengxiao Si,
David M. Young,
Hua Huang,
Yingxue Wang,
Qin Li,
Sang Yong Jung,
Xiaohong Xu (),
Pei Zhang () and
Yu Fu ()
Additional contact information
Esra Senol: Agency for Science Technology and Research (A*STAR)
Menghan Wang: Agency for Science Technology and Research (A*STAR)
Yongjuan Xin: Agency for Science Technology and Research (A*STAR)
Zhuolei Jiao: Chinese Academy of Sciences
Hasan Mohammad: Agency for Science Technology and Research (A*STAR)
Xin Yi Yeo: Agency for Science Technology and Research (A*STAR)
Tengxiao Si: Chinese Academy of Sciences
David M. Young: San Francisco
Hua Huang: National University of Singapore
Yingxue Wang: Agency for Science Technology and Research (A*STAR)
Qin Li: Chinese Academy of Sciences
Sang Yong Jung: Agency for Science Technology and Research (A*STAR)
Xiaohong Xu: Fudan University
Pei Zhang: Agency for Science Technology and Research (A*STAR)
Yu Fu: Agency for Science Technology and Research (A*STAR)
Nature Communications, 2025, vol. 16, issue 1, 1-16
Abstract:
Abstract Feeding is an innate behavior critical for survival but is also influenced by many non-nutritional factors such as emotion, social context and environmental conditions. Recently, tuberal nucleus somatostatin (TNSST) neurons have been identified as a key feeding regulation node. To gain a deeper understanding of the TNSST neural networks, we quantitatively characterised the brain-wide input-output configuration of mice TNSST neurons using the VITALISTIC method (Viral Tracing Assisted by Light-Sheet microscope and Tissue Clearing) and single-cell projectomes by fluorescence micro-optical sectioning tomography (fMOST). We found that TNSST neurons receive direct inputs from and send outputs to a broad range of brain regions, including many cortical and subcortical areas. Differently from AgRP neurons, the extensively studied ‘hunger’ neurons, TNSST neurons receive more diverse inputs from extra-hypothalamic regions and neuromodulatory centers. Using the projection-specific input tracing, we further revealed fine-tuning of the input-output configuration of TNSST neurons that align with specific functional needs.
Date: 2025
References: Add references at CitEc
Citations:
Downloads: (external link)
https://www.nature.com/articles/s41467-025-60585-9 Abstract (text/html)
Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.
Export reference: BibTeX
RIS (EndNote, ProCite, RefMan)
HTML/Text
Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60585-9
Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/
DOI: 10.1038/s41467-025-60585-9
Access Statistics for this article
Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie
More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().