Distinct subnetworks of the mouse anterior thalamic nuclei

Houri Hintiryan (), Mitchell Rudd, Sumit Nanda, Adriana E. Gutierrez, Darrick Lo, Tyler Boesen, Luis Garcia, Jiandong Sun, Christian Estrada, Hyun-Seung Mun, Seita Yamashita, Yeji E. Han, Ian Bowman, Lin Gou, Chunru Cao, Jennifer Gonzalez, Keivan Moradi, Qiuying Zhao, Inga Yenokian, Aishwarya Dev, Brian Zingg, Hanpeng Xu, Qing Xue, Muye Zhu, Lijuan Liu, Xin Chen, Zhixi Yun, Hanchuan Peng, Nicholas N. Foster and Hong-Wei Dong ()
Additional contact information
Houri Hintiryan: University of California Los Angeles
Mitchell Rudd: University of California Los Angeles
Sumit Nanda: University of California Los Angeles
Adriana E. Gutierrez: University of California Los Angeles
Darrick Lo: University of California Los Angeles
Tyler Boesen: University of California Los Angeles
Luis Garcia: University of California Los Angeles
Jiandong Sun: University of California Los Angeles
Christian Estrada: University of California Los Angeles
Hyun-Seung Mun: University of California Los Angeles
Seita Yamashita: University of California Los Angeles
Yeji E. Han: University of California Los Angeles
Ian Bowman: University of California Los Angeles
Lin Gou: University of California Los Angeles
Chunru Cao: University of California Los Angeles
Jennifer Gonzalez: University of California Los Angeles
Keivan Moradi: University of California Los Angeles
Qiuying Zhao: University of California Los Angeles
Inga Yenokian: University of California Los Angeles
Aishwarya Dev: University of California Los Angeles
Brian Zingg: University of California Los Angeles
Hanpeng Xu: University of California Los Angeles
Qing Xue: University of California Los Angeles
Muye Zhu: University of California Los Angeles
Lijuan Liu: Southeast University
Xin Chen: Southeast University
Zhixi Yun: Southeast University
Hanchuan Peng: Fudan University
Nicholas N. Foster: University of California Los Angeles
Hong-Wei Dong: University of California Los Angeles

Nature Communications, 2025, vol. 16, issue 1, 1-26

Abstract: Abstract Currently, classification of neuron types in the mouse thalamus remains largely incomplete. The anterior thalamic nuclei (ATN), a Papez circuit component, encompass the anterodorsal (AD), anteroventral (AV), and anteromedial (AM) thalamic nuclei. Structurally, the ATN facilitate communication among the neocortex, hippocampus, amygdala, and hypothalamus. Functionally, they play pivotal roles in learning, memory, spatial navigation, and goal-directed behaviors. Therefore, the ATN provide a promising avenue to investigate the relationship between structural and functional complexity with neuron type diversity. In male mice, comprehensive, systematically collected, pathway tracing data revealed several connectionally unique ATN cell populations, suggesting multiple parallel subnetworks run through each nucleus. Further, we applied genetic sparse labeling, brain clearing, 3D microscopic imaging, and computational informatics to morphologically characterize and catalog ATN neuron types. This study provides insights into how the prefrontal cortex, hippocampus, and amygdala interact through neuron type-specific ATN subnetworks to coordinate cognitive and emotional aspects of goal-directed behavior.

Date: 2025
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DOI: 10.1038/s41467-025-60774-6

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