Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks

Giovanni Davide Barone (), Ina Somvilla, Hannah Pia Franziska Meier, Anna Christina R. Ngo, Thomas Bayer, Fabio Parmeggiani, Viktoria Rehbein, Johann A. Hlina, Pablo Domínguez de María, Uwe T. Bornscheuer, Dirk Tischler and Sandy Schmidt ()
Additional contact information
Giovanni Davide Barone: University of Graz
Ina Somvilla: University of Greifswald
Hannah Pia Franziska Meier: University of Groningen
Anna Christina R. Ngo: Ruhr University Bochum
Thomas Bayer: University of Greifswald
Fabio Parmeggiani: Polytechnic of Milan
Viktoria Rehbein: University of Graz
Johann A. Hlina: University of Graz
Pablo Domínguez de María: Sustainable Momentum SL
Uwe T. Bornscheuer: University of Greifswald
Dirk Tischler: Ruhr University Bochum
Sandy Schmidt: University of Groningen

Nature Communications, 2025, vol. 16, issue 1, 1-17

Abstract: Abstract Chemicals produced through enzymatic reactions play a key role in the transition from a linear petrol-dependent to a circular bioeconomy. One promising approach is the conversion of single carbon (C1) molecules by biocatalysts to value-added products. Although progress has been made, current biological methods remain less cost-competitive than established chemical processes. Here, we review how single and multi-enzyme transformations, natural C1-trophic microorganisms, and organisms with transplanted synthetic C1 assimilation pathways can synergize to strengthen the competitiveness of C1-based biomanufacturing. To explore the current state-of-the-art and assess the potential of C1 biomanufacturing, we highlight the aforementioned bio-based methodologies and evaluate their industrial applicability through an overview of granted patents.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-60777-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60777-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-60777-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().