Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study

Yuxia Wei (), Tomas Andersson, Shengxin Liu, Maria Feychting, Ralf Kuja-Halkola and Sofia Carlsson ()
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Yuxia Wei: Karolinska Institutet
Tomas Andersson: Karolinska Institutet
Shengxin Liu: Karolinska Institutet
Maria Feychting: Karolinska Institutet
Ralf Kuja-Halkola: Karolinska Institutet
Sofia Carlsson: Karolinska Institutet

Nature Communications, 2025, vol. 16, issue 1, 1-9

Abstract: Abstract Incidence of type 1 diabetes is increasing globally, which is hypothesized to be due to environmental influences. We leverage Swedish nationwide registers linked to all children (n = 2,928,704) born in 1982–2010 to investigate if the heritability of childhood-onset type 1 diabetes has changed over time and how alterations in environmental factors have contributed to the rising type 1 diabetes incidence. The heritability is estimated at 0.83 (95% confidence interval: 0.79, 0.86) and stable over the observation period (0.80 [0.71, 0.86] in 1982, 0.83 [0.79, 0.86] in 2000, and 0·83 [0.79, 0.86] in 2010, respectively). Environmental factors including maternal smoking during pregnancy and childhood adiposity explain

Date: 2025
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DOI: 10.1038/s41467-025-60813-2

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