Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models

Shiya Lv, Fan Mo, Zhaojie Xu, Yu Wang, Yaoyao Liu, Meiqi Han, Yiming Duan, Luyi Jing, Fanli Kong, Qianli Jia, Ming Li, Wei Xu, Peiyao Jiao, Mixia Wang, Juntao Liu, Jinping Luo, Junbo Wang, Zhongwei Fan, Yilin Song (), Yirong Wu () and Xinxia Cai ()
Additional contact information
Shiya Lv: Chinese Academy of Sciences
Fan Mo: Chinese Academy of Sciences
Zhaojie Xu: Chinese Academy of Sciences
Yu Wang: Chinese Academy of Sciences
Yaoyao Liu: Chinese Academy of Sciences
Meiqi Han: Chinese Academy of Sciences
Yiming Duan: Chinese Academy of Sciences
Luyi Jing: Chinese Academy of Sciences
Fanli Kong: Chinese Academy of Sciences
Qianli Jia: Chinese Academy of Sciences
Ming Li: Chinese Academy of Sciences
Wei Xu: Chinese Academy of Sciences
Peiyao Jiao: Chinese Academy of Sciences
Mixia Wang: Chinese Academy of Sciences
Juntao Liu: Chinese Academy of Sciences
Jinping Luo: Chinese Academy of Sciences
Junbo Wang: Chinese Academy of Sciences
Zhongwei Fan: Chinese Academy of Sciences
Yilin Song: Chinese Academy of Sciences
Yirong Wu: Chinese Academy of Sciences
Xinxia Cai: Chinese Academy of Sciences

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract Hippocampal degeneration and reduced dopamine levels in Alzheimer’s disease are associated with severe memory and cognitive impairments. However, the lack of multifunctional in situ neural chips has posed challenges for integrated investigations of Alzheimer’s disease pathophysiology, dopamine dynamics, and neural activity. Therefore, we developed NeuroRevive-FlexChip, a flexible neural interface capable of precise electrical modulation and simultaneous in situ monitoring of dopamine levels and neural activity. In this study, the NeuroRevive-FlexChip demonstrates improved electrochemical detection sensitivity and modulation efficiency. Preliminary observations in APP/PS1 mice indicate that implantation of the chip in the hippocampal CA1 region, combined with 40 Hz stimulation, may contribute to the restoration of dopamine release, a reduction in neuronal hyper-synchronization, and a shift toward more stable firing patterns. These effects appear to be modulated by dopamine-related mechanisms. Furthemore, 40 Hz stimulation was observed to correlate with reduction in Aβ42 deposition and modest improvements in spatial cognition performance, as assessed by the Y-maze test. These findings highlight the potential of NeuroRevive-FlexChip as a research tool for investigating the mechanisms of 40 Hz stimulation in Alzheimer’s disease models. Further studies could explore its utility in clarifying the relationship between dopamine dysfunction, neural activity, and amyloid pathology. While these early results are promising, additional preclinical and translational research will be necessary to assess the therapeutic potential of this approach for neurodegenerative diseases.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-60903-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60903-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-60903-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().