Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice

Enrica Montalban (), Anthony Ansoult, Daniela Herrera Moro Chao, Cuong Pham, Clara Franco, Andrea Contini, Julien Castel, Rim Hassouna, Marene H. Hardonk, Anna Petitbon, Ewout Foppen, Giuseppe Gangarossa, Pierre Trifilieff, Dongdong Li, Serge Luquet () and Claire Martin ()
Additional contact information
Enrica Montalban: Unité de Biologie Fonctionnelle et Adaptative
Anthony Ansoult: Unité de Biologie Fonctionnelle et Adaptative
Daniela Herrera Moro Chao: Unité de Biologie Fonctionnelle et Adaptative
Cuong Pham: Neuro-SU
Clara Franco: Neuro-SU
Andrea Contini: UMR 1286
Julien Castel: Unité de Biologie Fonctionnelle et Adaptative
Rim Hassouna: Unité de Biologie Fonctionnelle et Adaptative
Marene H. Hardonk: Unité de Biologie Fonctionnelle et Adaptative
Anna Petitbon: UMR 1286
Ewout Foppen: Unité de Biologie Fonctionnelle et Adaptative
Giuseppe Gangarossa: Unité de Biologie Fonctionnelle et Adaptative
Pierre Trifilieff: UMR 1286
Dongdong Li: Neuro-SU
Serge Luquet: Unité de Biologie Fonctionnelle et Adaptative
Claire Martin: Unité de Biologie Fonctionnelle et Adaptative

Nature Communications, 2025, vol. 16, issue 1, 1-17

Abstract: Abstract Brain circuits in reward-associated behaviors are potent drivers of feeding behavior but also recently emerged as regulator of metabolism. Short or chronic exposures to caloric food alter brain structures and are associated with increased astrocytes reactivity and pro-inflammatory responses in both mice and humans. However, the role of striatal astrocytes in regulating adaptive and maladaptive behavioral and metabolic responses to energy-dense food remains elusive. In this study we reveal that chemogenetic manipulation of the astrocytes in striatal structures can exert a direct effect on peripheral metabolism in male mice, and that manipulation of astrocytes in the dorsal striatum can alter peripheral metabolism and is sufficient to restore cognitive deficit induced by chronic high fat high sucrose (HFHS) diet exposure in obese mice. Altogether, this work reveals a yet unappreciated role for striatal astrocytes as a direct operator of flexible behavior and metabolic control.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-60968-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60968-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-60968-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().