Noncanonical short-latency auditory pathway directly activates deep cortical layers

Michellee M. Garcia, Amber M. Kline, Koun Onodera, Hiroaki Tsukano, Pranathi R. Dandu, Hailey C. Acosta, Michael R. Kasten, Paul B. Manis and Hiroyuki K. Kato ()
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Michellee M. Garcia: University of North Carolina at Chapel Hill
Amber M. Kline: University of North Carolina at Chapel Hill
Koun Onodera: University of North Carolina at Chapel Hill
Hiroaki Tsukano: University of North Carolina at Chapel Hill
Pranathi R. Dandu: University of North Carolina at Chapel Hill
Hailey C. Acosta: University of North Carolina at Chapel Hill
Michael R. Kasten: University of North Carolina at Chapel Hill
Paul B. Manis: University of North Carolina at Chapel Hill
Hiroyuki K. Kato: University of North Carolina at Chapel Hill

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract Auditory processing in the cerebral cortex is considered to begin with thalamocortical inputs to layer 4 (L4) of the primary auditory cortex (A1). In this canonical model, A1 L4 inputs initiate a hierarchical cascade that propagates to higher-order cortices for slower integration of complex sounds. Here, we identify parallel ascending pathways in mice that bypass A1 and directly reach the secondary auditory cortex (A2), alongside the canonical hierarchical route. We found that layer 6 (L6) of both A1 and A2 receive short-latency (

Date: 2025
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DOI: 10.1038/s41467-025-61020-9

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