Dimeric copper peptide incorporated hydrogel for promoting diabetic wound healing

Rui Cong, Chengyu Deng, Pengwei Li, Yiwei Tang, Jinfan Hou, Jiehui Zhao, Qili Wang, Yingying Chen, Jiasheng Tu (), Xiqun Jiang () and Lei Jiang ()
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Rui Cong: China Pharmaceutical University
Chengyu Deng: China Pharmaceutical University
Pengwei Li: China Pharmaceutical University
Yiwei Tang: China Pharmaceutical University
Jinfan Hou: China Pharmaceutical University
Jiehui Zhao: China Pharmaceutical University
Qili Wang: China Pharmaceutical University
Yingying Chen: University of Illinois at Urbana-Champaign
Jiasheng Tu: China Pharmaceutical University
Xiqun Jiang: Nanjing University
Lei Jiang: China Pharmaceutical University

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract Diabetic wounds require continuous and coordinated modulation of the microenvironment concurrent with tissue regeneration, which remains a significant challenge. As a proof of concept, we herein propose to use dimeric copper peptide (D-CuP) for diabetic wound treatment. The D-CuP is synthesized and then incorporated into a reactive oxygen species (ROS)-responsive hydrogel matrix to improve therapeutic compliance, culminating in the formulation of G/D-CuP. Compared to monomer copper peptide (M-CuP), a wound healing agent, D-CuP exhibits multivalency, enhanced biological stability against proteases, and broad biological activities. Meanwhile, the hydrogel matrix, exhibiting ROS-scavenging capabilities, has been engineered to be an intelligent drug reservoir for wound-responsive release of D-CuP at the wound site while simultaneously attenuating inflammatory responses. Ultimately, the G/D-CuP group demonstrates superior therapeutic efficacy, achieving 97.2% closure of infected wounds.

Date: 2025
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DOI: 10.1038/s41467-025-61141-1

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