Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging

Ye Yang, Binlong Chen, Fangjie Wan, Chuanxun Fu, Meifang Chen, Bin Ma, Ruiyang Zhao, Meijie Pan, Qiang Zhang and Yiguang Wang ()
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Ye Yang: Peking University
Binlong Chen: Peking University
Fangjie Wan: Peking University
Chuanxun Fu: Peking University
Meifang Chen: Peking University
Bin Ma: Peking University
Ruiyang Zhao: Peking University
Meijie Pan: Peking University
Qiang Zhang: Peking University
Yiguang Wang: Peking University

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract The pH in organisms is strictly regulated within an appropriate range for homeostasis, and many pathological processes often result in pH dysregulation to distinct intervals that serves as targets for diagnosis and treatment. Thus, a mechanism of selective and gating response for different proton levels in an integrated nanodevice is needed to report acidic biological environments with specific pH dynamic ranges. Here we report the design of band-pass light-up nanokits (BLINK) with pH heterogating capacity in opposite directions to achieve selective reporting of the acidic intervals (minimum to 0.25 pH unit) of pathophysiological environments. The proton heterogated property of BLINK integrates ultra-fast (

Date: 2025
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DOI: 10.1038/s41467-025-61255-6

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