A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Xingcan Huang, Qiang Zhang, Yawen Yang, Lung Chow, Jie Ma, Guoqiang Xu, Fang Guo, Xinxin He, Zhiyuan Li, Guangyao Zhao, Jingyou Su, Guihuan Guo, Jiachen Wang, Yanli Jiao, Zhan Gao, Jiyu Li, Jingkun Zhou, Chun Ki Yiu, Jian Li, Yi Chen, Pengcheng Wu, Kuanming Yao, Yiming Liu, Dengfeng Li, Binbin Zhang, Hongwei Chu, Yue Hu, Ya Huang, Zhenlin Chen, Kangning Ren, Bo Fang, Rungong Yang (), Heng Li (), Xiaoming Tao (), Xiaohui Ma () and Xinge Yu ()
Additional contact information
Xingcan Huang: City University of Hong Kong
Qiang Zhang: City University of Hong Kong
Yawen Yang: City University of Hong Kong
Lung Chow: City University of Hong Kong
Jie Ma: The Hong Kong Polytechnic University
Guoqiang Xu: City University of Hong Kong
Fang Guo: The University of Hong Kong
Xinxin He: City University of Hong Kong
Zhiyuan Li: City University of Hong Kong
Guangyao Zhao: City University of Hong Kong
Jingyou Su: Hong Kong Baptist University
Guihuan Guo: City University of Hong Kong
Jiachen Wang: City University of Hong Kong
Yanli Jiao: City University of Hong Kong
Zhan Gao: City University of Hong Kong
Jiyu Li: City University of Hong Kong
Jingkun Zhou: City University of Hong Kong
Chun Ki Yiu: City University of Hong Kong
Jian Li: City University of Hong Kong
Yi Chen: Sichuan University
Pengcheng Wu: City University of Hong Kong
Kuanming Yao: City University of Hong Kong
Yiming Liu: City University of Hong Kong
Dengfeng Li: City University of Hong Kong
Binbin Zhang: City University of Hong Kong
Hongwei Chu: City University of Hong Kong
Yue Hu: City University of Hong Kong
Ya Huang: City University of Hong Kong
Zhenlin Chen: City University of Hong Kong
Kangning Ren: Hong Kong Baptist University
Bo Fang: The Hong Kong Polytechnic University
Rungong Yang: The first medical center of Chinese PLA General Hospital
Heng Li: The Hong Kong Polytechnic University
Xiaoming Tao: The Hong Kong Polytechnic University
Xiaohui Ma: The first medical center of Chinese PLA General Hospital
Xinge Yu: City University of Hong Kong

Nature Communications, 2025, vol. 16, issue 1, 1-17

Abstract: Abstract Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.

Date: 2025
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DOI: 10.1038/s41467-025-61261-8

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