Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants

Franz Förster (), David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel, Michele Filosi, Myriam Fornage, Martin Gögele, Markus Löffler, Thomas H. Mosley, Cristian Pattaro, Peter Pramstaller, Srishti Shrestha, N. Ahmad Aziz, Monique M. B. Breteler, Kerstin Wirkner, Markus Scholz () and Christian Fuchsberger ()
Additional contact information
Franz Förster: Leipzig University
David Emmert: Eurac Research
Katrin Horn: Leipzig University
Janne Pott: Leipzig University
Johannes Frasnelli: Eurac Research
Mohammed Aslam Imtiaz: Population Health Sciences
Konstantinos Melas: Population Health Sciences
Valentina Talevi: Population Health Sciences
Honglei Chen: Michigan State University
Christoph Engel: Leipzig University
Michele Filosi: Eurac Research
Myriam Fornage: University of Texas Health Science at Houston
Martin Gögele: Eurac Research
Markus Löffler: Leipzig University
Thomas H. Mosley: University of Mississippi Medical Center
Cristian Pattaro: Eurac Research
Peter Pramstaller: Eurac Research
Srishti Shrestha: University of Mississippi Medical Center
N. Ahmad Aziz: Population Health Sciences
Monique M. B. Breteler: Population Health Sciences
Kerstin Wirkner: Leipzig University
Markus Scholz: Leipzig University
Christian Fuchsberger: Eurac Research

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract Smelling is a human sense, expressing strong sexual dimorphisms. We aim to improve the knowledge of the genetics of human olfactory perception by performing an exploratory genome-wide association meta-analysis of up to 21,495 individuals of European ancestry. By sex-stratified and overall analysis of the identification of twelve odours and an identification score, we discovered ten independent loci, seven of them novel, with trait-wise genome-wide significance (p

Date: 2025
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DOI: 10.1038/s41467-025-61330-y

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