Vinyl cyclopropanes as a unifying platform for enantioselective remote difunctionalization of alkenes

Xiaoyong Du, Marc E. Lennon, Georgia Kriticou and Cristina Nevado ()
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Xiaoyong Du: University of Zurich
Marc E. Lennon: University of Zurich
Georgia Kriticou: University of Zurich
Cristina Nevado: University of Zurich

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract Asymmetric remote difunctionalization of alkenes is a longstanding challenge in synthetic chemistry, offering the potential to install two functional groups simultaneously across distal carbon atoms in a stereocontrolled manner. While ingenious strategies have been devised to achieve this transformation, a general catalytic system for remote, enantioselective hetero-carbofunctionalization and dicarbofunctionalization of alkenes has remained elusive. Here, we present a nickel/photoredox dual-catalyzed asymmetric remote 1,5-carbosulfonylation and 1,5-dicarbofunctionalization of vinyl cyclopropanes. This cascade reaction integrates radical addition, C–C bond cleavage, and cross-coupling to functionalize two distal carbon atoms with high enantioselectivity. Our protocol demonstrates broad substrate scope, excellent functional group tolerance, and significant synthetic utility, as evidenced by late-stage functionalization and product derivatization. Our mechanistic investigations support the involvement of a Ni(0)/Ni(I)/Ni(III) catalytic cycle in our system. This work establishes a versatile platform for remote alkene difunctionalization, expanding the toolbox of enantioselective synthetic methods and unlocking new avenues for complex molecule construction.

Date: 2025
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DOI: 10.1038/s41467-025-61363-3

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