Iron(III)-catalyzed activation of C(sp2)-H and C(sp3)-H bonds for H/D exchange of arenes

Chang Zheng, Yu Tang () and Biao Yu ()
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Chang Zheng: University of Chinese Academy of Sciences
Yu Tang: Chinese Academy of Sciences
Biao Yu: University of Chinese Academy of Sciences

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract Iron-catalyzed C-H activation reactions via organometallic Fe-C intermediates have been extensively studied during the past two decades. One issue remains to be clarified is whether iron(III) salts containing weakly coordinating anions could directly activate C(sp2)-H or C(sp3)-H bonds without the assistance of a directing group. Herein, we report our finding that iron(III) salts containing weakly coordinating anions can indeed be effective catalyst for the direct activation of C(sp2)-H and C(sp3)-H bonds under weakly coordinating environment. This mechanism could be extended to other types of first-row transition metal complexes such as Co(II), Ni(II), and Cu(II). Thus, an iron(III) catalyzed H/D exchange reaction for aromatic C(sp2)-H bonds and the corresponding β-C(sp3)-H bonds of the alkyl substituents is developed, unlocking an easy access to the valuable deuterated aromatic products from feedstock chemicals.

Date: 2025
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DOI: 10.1038/s41467-025-61428-3

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