Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory

Tung V. To, David X. Wang, Cody B. Wolfe and Bradley C. Lega ()
Additional contact information
Tung V. To: UT Southwestern Medical Center
David X. Wang: UT Southwestern Medical Center
Cody B. Wolfe: UT Southwestern Medical Center
Bradley C. Lega: UT Southwestern Medical Center

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract In humans, the hippocampus exhibits evident structural and connectivity differences along the longitudinal axis. Experiments in rodents and more recently in human subjects have stimulated several theories of functional longitudinal specialization. This question pertains directly to the management of neurosurgical patients, as nascent technologies permit more precise treatments that can selectively spare longitudinal regions. With this in mind, we investigated hippocampal longitudinal specialization in 32 human intracranial EEG subjects as they performed an associative recognition episodic memory task. Utilizing the behavioral contrasts available in this task, we characterize the neurophysiological features that distinguish the anterior versus posterior hippocampal activity during recollection and familiarity–based memory retrieval, as well as novelty processing. We use subspace representations to characterize longitudinal differences in the temporal dynamics of key computational processes ascribed to the hippocampus, namely pattern separation and pattern completion. We place our findings in the context of existing models, adding to sparse literature using direct brain recordings to explicate the functional differentiation along the hippocampal longitudinal axis in humans.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-61464-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61464-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-61464-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().