Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor

Dalia Martinez-Marin, Monica Sharma, Jenna C. Wunnik, Flávia Sardela de Miranda, Geetha Priya Boligala, Ella C. Jull, Grace C. Stroman, Rachel L. Babcock and Kevin Pruitt ()
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Dalia Martinez-Marin: University of North Carolina
Monica Sharma: Texas Tech University HSC
Jenna C. Wunnik: Texas Tech University
Flávia Sardela de Miranda: Texas Tech University HSC
Geetha Priya Boligala: Texas Tech University HSC
Ella C. Jull: University of North Carolina
Grace C. Stroman: University of North Carolina
Rachel L. Babcock: Texas Tech University HSC
Kevin Pruitt: University of North Carolina

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract Dishevelled (DVL) is a crucial component of the Wnt-signaling pathway and is vital for multiple physiological processes. Previously thought to have a classically cytoplasmic role, the discovery of DVL nuclear translocation reframed how it is viewed functionally. Although significant progress has been made in understanding the nuclear functions of DVL, further research is required to clarify its roles in transcriptional and epigenetic regulation. A key unresolved question is whether nuclear DVL1 associates with a transcription factor partner. We show here that modulation of DVL1 expression globally affects the transcriptomic landscape. Additionally, analysis of DVL1 ChIP-sequencing allowed us to map genome-wide binding sites, revealing the extensive reach of DVL1 binding. Integration of RNA-sequencing and ChIP-sequencing further revealed ETS1 as a transcription factor binding partner which targets nuclear DVL1 to specific genomic loci. These findings provide insight into the contribution of DVL1 in transcription and clarify aspects of its elusive nuclear function.

Date: 2025
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DOI: 10.1038/s41467-025-61551-1

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