Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications

Zhou Gao, Christopher Rensing (), Jie Wang, Chenhui Shen, Mohammed Esmail Abdalla Elzaki, Xiaoyun Li, Jinfang Tan and Xiaoqian Jiang ()
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Zhou Gao: Sun Yat-sen University
Christopher Rensing: Fujian Agriculture and Forestry University
Jie Wang: Fujian Agriculture and Forestry University
Chenhui Shen: Oil Crops Research Institute of Chinese Academy of Agricultural Science
Mohammed Esmail Abdalla Elzaki: Fujian Agriculture and Forestry University
Xiaoyun Li: Sun Yat-sen University
Jinfang Tan: Sun Yat-sen University
Xiaoqian Jiang: Sun Yat-sen University

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract RNA interference is an eco-friendly alternative to chemical pesticides, yet its efficacy in lepidopterans like Spodoptera frugiperda (S. frugiperda) is limited by poor uptake. Here, we report on ZIF-8 polydopamine nanoparticles that protect dsRNA against enzymatic degradation and active the endocytic/phagosome pathways for increased uptake. Furthermore, the uptake of nano-enabled dsRNA induces the overgrowth of Serratia marcescens, this reduces the S. frugiperda reactive oxygen species (ROS) immune response, increasing the effects of plant’s natural defenses, further inhibiting Enteroccous mundtii growth. This work shows the synergistic potential of nanoparticles for influencing the gut bacteria to prevent resistance mechanisms and for RNAi delivery for pest management.

Date: 2025
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DOI: 10.1038/s41467-025-61604-5

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