Stem cell secretome armed magneto-actuated micromotors as spatio-temporal manipulators for wound healing acceleration

Jiamiao Jiang, Haiying Liang, Yicheng Ye, Weichang Huang, Jiajun Miao, Haixin Tan, Ziwei Hu, Hao Tian, Hanfeng Qin, Xiaoting Zhang, Lishan Zhang, Junbin Gao, Xian Shen (), Shuanghu Wang (), Fei Peng () and Yingfeng Tu ()
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Jiamiao Jiang: Southern Medical University
Haiying Liang: Southern Medical University
Yicheng Ye: Southern Medical University
Weichang Huang: Southern Medical University
Jiajun Miao: Southern Medical University
Haixin Tan: Southern Medical University
Ziwei Hu: Southern Medical University
Hao Tian: Southern Medical University
Hanfeng Qin: Southern Medical University
Xiaoting Zhang: Southern Medical University
Lishan Zhang: Southern Medical University
Junbin Gao: Southern Medical University
Xian Shen: The First Affiliated Hospital of Wenzhou Medical University
Shuanghu Wang: Lishui People’s Hospital
Fei Peng: Sun Yat-Sen University
Yingfeng Tu: Southern Medical University

Nature Communications, 2025, vol. 16, issue 1, 1-19

Abstract: Abstract Healing complex wounds, especially deep injuries, requires therapies that can target different healing phases while penetrating physical barriers like fibrin clots and scab. Existing approaches fail to fully address these spatiotemporal challenges due to reliance on passive drug diffusion. Here, we develop magnetic microspheres loaded with therapeutic factors derived from stem cells (collectively called the “secretome”) to actively guide wound repair. These microspheres provide sustained release of bioactive factors and can be precisely navigated using external magnetic fields. In vitro, they exhibit potent anti-inflammatory effects and progressively enhance skin cell proliferation and migration. Unlike conventional therapies, magnetic propulsion allows them to penetrate dense wound barriers more effectively. In male murine full-thickness wounds, the micromotors accelerate healing by promoting tissue regeneration, reducing inflammation, and improving collagen and blood vessel formation. Successful results in male pigs further confirm their cross-species potential. By combining magnetic mobility with a composite bioactive secretome, this platform overcomes both spatial and temporal limitations in wound treatment.

Date: 2025
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DOI: 10.1038/s41467-025-61914-8

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