EconPapers    
Economics at your fingertips  
 

Regulatory interaction between metabolite transporters coordinates glucose and exometabolite fluxes to drive bioenergetics

Noa Yehoshua, Ahlam Khamaysi, Liana Shimshilashvili, Aharon Keshet, Mahmoud Taha, Moran Fremder, Hadar Eini-Rider and Ehud Ohana ()
Additional contact information
Noa Yehoshua: Ben Gurion University of the Negev
Ahlam Khamaysi: Ben Gurion University of the Negev
Liana Shimshilashvili: Ben Gurion University of the Negev
Aharon Keshet: Ben Gurion University of the Negev
Mahmoud Taha: Ben Gurion University of the Negev
Moran Fremder: Ben Gurion University of the Negev
Hadar Eini-Rider: Ben Gurion University of the Negev
Ehud Ohana: Ben Gurion University of the Negev

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract The composition of tricarboxylic acid cycle metabolites in the external environment of cells determines vital physiological functions, including nutrient and mineral absorption, inflammation, and cellular energy management. Here, we study how the transport of external metabolites into the cells functions as an independent metabolic pathway that controls cellular energy. We show that liver cells orchestrate simultaneous fluxes of glucose and the omnipotent metabolite citrate across the cell membrane, acting as a first line metabolic pathway that responds to nutrient availability. Using functional mapping and gene silencing, we delineate the underlying molecular mechanism showing that the liver citrate transporter (NaCT) interacts with glucose transporters (Glut) and the anion transporters. The interaction is mediated by a specific region of the NaCT protein to reciprocally regulate the transport functions. Our findings describe an independent mechanism that coordinates external metabolites and glucose balance, thus driving key energy management processes in response to nutrient availability in the liver.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-62103-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62103-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-62103-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().

 
Page updated 2025-07-26
Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62103-3