P-stereogenic centre via Pd/Cu-bimetallic catalytic selective phosphinylation of allenylic acetates

Gen Li, Shichao Hong, Xuechen Li, Wenhao Zhao, Chaobo Ye, Yi Yu, Huajie Jiang, Jie Yu, Xue Zhang (), Shengming Ma () and Qiankun Li ()
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Gen Li: Anhui Agricultural University
Shichao Hong: Fudan University
Xuechen Li: Anhui Agricultural University
Wenhao Zhao: Anhui Agricultural University
Chaobo Ye: Anhui Agricultural University
Yi Yu: Anhui Agricultural University
Huajie Jiang: Anhui Agricultural University
Jie Yu: Anhui Agricultural University
Xue Zhang: University of Chinese Academy of Sciences
Shengming Ma: Fudan University
Qiankun Li: Anhui Agricultural University

Nature Communications, 2025, vol. 16, issue 1, 1-9

Abstract: Abstract P-stereogenic organophosphorus compounds are a class of highly important compounds due to their potentials in asymmetric catalysis both as ligands or catalysts and medicinal chemistry. Herein, we report an efficient protocol under bimetallic catalysis of Pd/Cu for highly regio-, E- and enantioselective phosphinylation of allenylic acetates with racemic secondary phosphine oxides forming a wide range of versatile P-stereogenic 1,3-dienyl phosphine oxides with 86–95% ee. The regioselectivity is unique as compared to the traditional catalytic enantioselective allenylations.

Date: 2025
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DOI: 10.1038/s41467-025-62204-z

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