Arbovirus suppression of a lectin protein-mediated broad-spectrum resistance enhances herbivorous vector performance and viral transmission

Zihang Yang, Wei Wu, Zhongtian Xu, Yanjun Li, Hehong Zhang, Lulu Li, Jianping Chen, Bingjian Sun and Zongtao Sun ()
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Zihang Yang: Henan Agricultural University
Wei Wu: Ningbo University
Zhongtian Xu: Ningbo University
Yanjun Li: Ningbo University
Hehong Zhang: Ningbo University
Lulu Li: Ningbo University
Jianping Chen: Henan Agricultural University
Bingjian Sun: Henan Agricultural University
Zongtao Sun: Ningbo University

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract Arboviruses often employ various strategies to manipulate the behavior of herbivorous vectors and host plants, thereby enhancing their transmission and infection. In this study, we identify a plant lectin protein, OsChtBL1, which possesses chitin-binding activity and specifically accumulates on the stylets of insect vectors. This binding creates a feeding barrier that reduces the vectors’ efficiency in acquiring and transmitting the virus. However, the rice stripe virus, a devastating pathogen in rice, counteracts this defense by utilizing a viral protein to recruit an E3 ubiquitin ligase, leading to the degradation of OsChtBL1. This degradation facilitates vector feeding and enhances viral transmission. Our findings provide insights into how arbovirus-infected host plants improve the performance of herbivorous vectors and offer deeper understanding of the complex interactions among arboviruses, vectors, and host plants.

Date: 2025
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DOI: 10.1038/s41467-025-62233-8

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