Health risks and genetic architecture of objectively measured multidimensional sleep health

Shengkui Zhang, Manrui Zhang, Yuxin Yuan, Zilin Li (), Xihao Li () and Xiaoyu Li ()
Additional contact information
Shengkui Zhang: Tsinghua University
Manrui Zhang: Tsinghua University
Yuxin Yuan: Northeast Normal University
Zilin Li: Northeast Normal University
Xihao Li: University of North Carolina at Chapel Hill
Xiaoyu Li: Tsinghua University

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract A multidimensional sleep health framework improves screening and treatment efficacy by simultaneously addressing multiple sleep domains. However, limited studies have used objective measures to evaluate the co-occurrence of diverse unhealthy sleep characteristics and their pleiotropic health effects. To represent real-world sleep patterns, we introduce the Unfavorable Sleep Profile (USP), an integrated multidimensional sleep health metric developed using accelerometer data in the UK Biobank (N = 85,233; aged 43–79 years). USP captures five domains: sleep timing, efficiency, duration, rhythmicity, and regularity. Phenome-wide association study found that USP was significantly associated with 76 out of 526 incident health outcomes over 7.9 years of follow-up. We identified several upstream environmental risk factors associated with USP, including low socioeconomic status. Whole-genome sequence analyses identified common variants in MEIS1 and rare coding variants in TTC1 associated with USP. We validated the USP framework in an independent cohort, the Multi-Ethnic Study of Atherosclerosis. Our findings underscore the importance of multidimensional sleep health assessment in predicting and potentially mitigating a wide array of health disorders and advance genetic insights into sleep health.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-62338-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62338-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-62338-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().