Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge

Julie C. Worrell (), Kerrie E. Hargrave, George E. Finney, Chris Hansell, John Cole, Jagtar Singh Nijjar, Fraser Morton, Marieke Pingen, Tom Purnell, Kathleen Mitchelson, Euan Brennan, Clíodhna M. Daly, Jay Allan, Georgios Ilia, Vanessa Herder, Claire Kennedy Dietrich, Yoana Doncheva, Nigel B. Jamieson, Massimo Palmarini and Megan K. L. MacLeod ()
Additional contact information
Julie C. Worrell: University of Glasgow
Kerrie E. Hargrave: University of Glasgow
George E. Finney: University of Glasgow
Chris Hansell: University of Glasgow
John Cole: University of Glasgow
Jagtar Singh Nijjar: Weatherden Ltd
Fraser Morton: University of Glasgow
Marieke Pingen: University of Glasgow
Tom Purnell: University of Glasgow
Kathleen Mitchelson: University of Glasgow
Euan Brennan: University of Glasgow
Clíodhna M. Daly: University of Glasgow
Jay Allan: MRC-University of Glasgow Centre for Virus Research
Georgios Ilia: MRC-University of Glasgow Centre for Virus Research
Vanessa Herder: MRC-University of Glasgow Centre for Virus Research
Claire Kennedy Dietrich: University of Glasgow
Yoana Doncheva: University of Glasgow
Nigel B. Jamieson: University of Glasgow
Massimo Palmarini: MRC-University of Glasgow Centre for Virus Research
Megan K. L. MacLeod: University of Glasgow

Nature Communications, 2025, vol. 16, issue 1, 1-21

Abstract: Abstract Lung structural cells form barriers against pathogens and trigger immune responses following infections. This leads to the recruitment of innate and adaptive immune cells some of which remain within the lung and contribute to enhanced pathogen control following subsequent infections. There is growing evidence that structural cells also display long-term changes following infection. Here we investigate long-term changes to mouse lung epithelial cells, fibroblasts, and endothelial cells following influenza virus infection finding that all three cell types maintain an imprint of the infection, particularly in genes linked to communication with T cells. MHCI and MHCII proteins continue to be expressed at higher levels in both differentiated epithelial cells and progenitor populations and several differentially expressed genes are downstream of the transcription factor, SpiB, a known orchestrator of antigen presentation. Lung epithelial cells from influenza-infected mice display functional changes, more rapidly controlling influenza virus than cells from naïve animals. This rapid anti-viral response and increased expression of molecules required to communicate with T cells demonstrates sustained and enhanced functions following infection. These data suggest lung structural cells display characteristics of immune memory which could affect outcomes that are protective in the context of infection or pathogenic in chronic inflammatory disorders.

Date: 2025
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DOI: 10.1038/s41467-025-62364-y

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