Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation

Shriya Srinivasan, Marc-Joseph Antonini, Amro Alshareef, Atharva Sahasrabudhe, Josh Jenkins, Keiko Ishida, Johannes Kuosmanen, Alison Hayward, Seokkee Min, Robert Langer, Polina Anikeeva () and Giovanni Traverso ()
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Shriya Srinivasan: Massachusetts Institute of Technology
Marc-Joseph Antonini: Massachusetts Institute of Technology
Amro Alshareef: Massachusetts Institute of Technology
Atharva Sahasrabudhe: Massachusetts Institute of Technology
Josh Jenkins: Massachusetts Institute of Technology
Keiko Ishida: Massachusetts Institute of Technology
Johannes Kuosmanen: Massachusetts Institute of Technology
Alison Hayward: Massachusetts Institute of Technology
Seokkee Min: Massachusetts Institute of Technology
Robert Langer: Massachusetts Institute of Technology
Polina Anikeeva: Massachusetts Institute of Technology
Giovanni Traverso: Massachusetts Institute of Technology

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract Gastrointestinal (GI) dysmotility and associated conditions affect over 20% of population, yet pharmacological, behavioural, and surgical interventions offer limited therapeutic efficacy. Targeted electrical stimulation addressing underlying neuromuscular pathology stands to transform our ability to treat dysmotility. Here, we developed a closed-loop GI neuroprosthesis which activates or relaxes GI tract musculature through electrochemical stimulation in response to sensed food stimuli. We additionally describe a tool supporting minimally invasive endoscopically guided implantation that can penetrate the mucosa, accurately localize the submucosa, and safely deploy this device to directly interface with the enteric nervous system. The neuroprosthesis enables generation of coordinated peristaltic waves, significantly increasing the motility rate in a swine model of oesophageal and stomach dysmotility (p

Date: 2025
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DOI: 10.1038/s41467-025-62413-6

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