Defining the cell and molecular origins of the primate ovarian reserve

Sissy E. Wamaitha, Ernesto J. Rojas, Francesco Monticolo, Fei-man Hsu, Enrique Sosa, Amanda M. Mackie, Kiana Oyama, Maggie Custer, Melinda Murphy, Diana J. Laird, Jian Shu, Jon D. Hennebold and Amander T. Clark ()
Additional contact information
Sissy E. Wamaitha: University of California Los Angeles
Ernesto J. Rojas: University of California, San Francisco
Francesco Monticolo: Harvard Medical School
Fei-man Hsu: University of California Los Angeles
Enrique Sosa: University of California Los Angeles
Amanda M. Mackie: University of California Los Angeles
Kiana Oyama: Oregon National Primate Research Center
Maggie Custer: Oregon National Primate Research Center
Melinda Murphy: Oregon National Primate Research Center
Diana J. Laird: University of California, San Francisco
Jian Shu: Harvard Medical School
Jon D. Hennebold: Oregon National Primate Research Center
Amander T. Clark: University of California Los Angeles

Nature Communications, 2025, vol. 16, issue 1, 1-17

Abstract: Abstract The primate ovarian reserve is established during late fetal development and consists of quiescent primordial follicles in the ovarian cortex each composed of granulosa cells surrounding an oocyte in dictate. As late stages of fetal development are not routinely accessible using human tissues, the current study exploits the evolutionary proximity of the rhesus macaque to investigate follicle formation in primates. Like in humans, the rhesus prenatal ovary develops multiple types of pre-granulosa cells in time and space, with primordial follicles deriving from later emerging pre-granulosa subtypes. In addition, our work shows that activated medullary follicles recruit fetal theca cells to establish a two-cell system for sex-steroid hormone production prior to birth, providing a cell-based explanation for mini puberty.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-62702-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62702-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-62702-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().