Enzymatic craftsmanship in collagen glycosylation

Susovon Ghosh, Dilip Kumar (), Bhaskar Mondal () and Trayambak Basak ()
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Susovon Ghosh: Indian Institute of Technology (IIT) Mandi
Dilip Kumar: Ashoka University
Bhaskar Mondal: Indian Institute of Technology (IIT) Mandi
Trayambak Basak: Indian Institute of Technology (IIT) Mandi

Nature Communications, 2025, vol. 16, issue 1, 1-4

Abstract: Collagen IV, a key structural protein of basement membranes, is vital for the development and survival of multicellular life forms. Its maturation relies on specific post-translational O- glycosylation, primarily mediated by lysyl hydroxylase-3 (LH3) and other glycosyltransferases, which sculpt collagen by modifying the hydroxylysine residues with sugar moieties.

Date: 2025
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DOI: 10.1038/s41467-025-62768-w

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