Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk

Zuyou Wu, Yang Yang, Caibo Ning, Jiali Li, Yimin Cai, Yanmin Li, Zilong Cao, Shuangshuang Tian, Jingyi Peng, Qianying Ma, Chunyi He, Shuting Xia, Jun Chen, Xiaoping Miao, Zhen Li (), Ying Zhu (), Qian Chu () and Jianbo Tian ()
Additional contact information
Zuyou Wu: Wuhan University
Yang Yang: Huazhong University of Science and Technology
Caibo Ning: Wuhan University
Jiali Li: Huazhong University of Science and Technology
Yimin Cai: Wuhan University
Yanmin Li: Wuhan University
Zilong Cao: Wuhan University
Shuangshuang Tian: Wuhan University
Jingyi Peng: Wuhan University
Qianying Ma: Wuhan University
Chunyi He: Wuhan University
Shuting Xia: Wuhan University
Jun Chen: Bayer Healthcare
Xiaoping Miao: Wuhan University
Zhen Li: Huazhong University of Science and Technology
Ying Zhu: Wuhan University
Qian Chu: Huazhong University of Science and Technology
Jianbo Tian: Wuhan University

Nature Communications, 2025, vol. 16, issue 1, 1-17

Abstract: Abstract Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. To identify its underlying genetic factors, we utilized a deep learning algorithm capable of quantifying bone marrow fat fraction (BMFF) in the vertebrae and proximal femur using magnetic resonance imaging data of over 38,000 UK Biobank participants. Genome-wide association analyses uncovered 373 significant BMFF-associated variants (P-value

Date: 2025
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DOI: 10.1038/s41467-025-62826-3

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