Modular synthesis of CF2-containing compounds with PhSO2CF2H reagent through difluoromethylene radical anion synthon strategy

Shuo Sun, Rulong Jia, Xin Zhou, Zhongyi Wang, Jian Rong, Chuanfa Ni and Jinbo Hu ()
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Shuo Sun: Chinese Academy of Sciences
Rulong Jia: Chinese Academy of Sciences
Xin Zhou: Chinese Academy of Sciences
Zhongyi Wang: Chinese Academy of Sciences
Jian Rong: Chinese Academy of Sciences
Chuanfa Ni: Chinese Academy of Sciences
Jinbo Hu: Chinese Academy of Sciences

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract Difluoromethylene moiety has gained widespread applications in pharmaceuticals, agrochemicals, and materials owing to its augmented lipophilicity and being bioisosteric to ethereal oxygen. Possessing two orthogonal reactivity modes for bridging an electrophile and a radical acceptor to give gem-difluorides (R1-CF2-R2), the efficient difluoromethylene radical anion synthon (diFRAS) has been long sought after. In this work, we successfully utilize the readily available difluoromethyl phenyl sulfone (PhSO2CF2H) to couple with electrophiles and radical acceptors, thereby enabling PhSO2CF2H to serve as a novel diFRAS in organic synthesis. The generation of radicals (•CF2R) via visible light-promoted homolytic cleavage of C−S bonds in (phenylsulfonyl)difluoromethylated derivatives (PhSO2CF2R) is the linchpin in the diFRAS strategy to construct gem-difluorides (R1-CF2-R2) with structural complexity.

Date: 2025
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DOI: 10.1038/s41467-025-62834-3

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