Dynamic pathways in energy landscapes guiding supramolecular Janus dendrimer self-assemblies between lamellar and cubic architectures

Jiabin Luan, Danni Wang, Niels P. Kok, Neshat Moslehi, Ilja K. Voets and Daniela A. Wilson ()
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Jiabin Luan: Radboud University
Danni Wang: Radboud University
Niels P. Kok: Radboud University
Neshat Moslehi: Eindhoven University of Technology
Ilja K. Voets: Eindhoven University of Technology
Daniela A. Wilson: Radboud University

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract Elaborate kinetic control enables supramolecular self-assemblies to deviate from equilibrium, depicting profound energy landscapes with remarkable structural and functional diversity. Despite this potential, achieving an energy landscape that encompasses lamellar and inverse cubic structures remains a significant challenge, contrasting with the sophisticated structural transformations naturally orchestrated by cellular systems. Here, we present a dynamic and minimalistic Janus dendrimer self-assembly system capable of reversibly transitioning between lamellar vesicles and inverse cubic structures. By exploiting temperature-triggered non-covalent interactions, including OEG interdigitation and hydrogen bonding, conformational flexibility, and molecular packing, we reveal a rich energy landscape featuring diverse assembly pathways spanning lamellar vesicles and inverse cubosomes. Our study not only enriches the structural versatility of Janus dendrimer assemblies but also provides a foundation for advancing supramolecular systems toward applications in biomedicine, catalysis, and beyond.

Date: 2025
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DOI: 10.1038/s41467-025-62866-9

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