Direct chiroptical correlation of dissymmetric crystal morphologies

Qiang Wen, Melissa Tan, Ofir Eisenberg, Hadar Nasi, Vlad Brumfeld, Akash Tiwari, Hai-Mu Ye, Bart Kahr (), Linda J. W. Shimon (), Michal Lahav () and Milko E. Boom ()
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Qiang Wen: Weizmann Institute of Science
Melissa Tan: New York University
Ofir Eisenberg: Weizmann Institute of Science
Hadar Nasi: Weizmann Institute of Science
Vlad Brumfeld: Weizmann Institute of Science
Akash Tiwari: New York University
Hai-Mu Ye: New York University
Bart Kahr: New York University
Linda J. W. Shimon: Weizmann Institute of Science
Michal Lahav: Weizmann Institute of Science
Milko E. Boom: Weizmann Institute of Science

Nature Communications, 2025, vol. 16, issue 1, 1-8

Abstract: Abstract The expression of molecular dissymmetry in crystal form has been studied since Pasteur correlated macroscopic and microscopic chirality by measuring the optical activity of solutions of enantiomorphous tartrate salt crystals. Here, we show a direct correlation between enantiomorphous metal-organic framework (MOF) crystals and the chirality of the molecular structure. The geometry of the habits is correlated with single-crystal optical activity along the accessible low-symmetry directions. Weak X-ray scattering from small crystals was consistent with a hexagonal, enantiomorphous space group. However, the heterochirality of the mirror image forms could not be established with X-rays, necessitating a different approach. The optical circular birefringence of the enantiomorphs as evidenced by chiroptical imaging with a complete polarimetric microscope, was used to correlate optical and morphological chirality.

Date: 2025
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DOI: 10.1038/s41467-025-62889-2

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