Bioinspired ruthenium-manganese-oxygen complex for biocatalytic and radiosensitization therapies to eradicate primary and metastatic tumors

Ruidan Li, Ting Wang, Shengdong Mu, Zhenyu Xing, Zhiying Ding, Qinlong Wen, Zhigong Wei, Xiaolin Wang, Mohsen Adeli, Shuang Li, Chong Cheng () and Xingchen Peng ()
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Ruidan Li: Sichuan University
Ting Wang: Sichuan University
Shengdong Mu: Sichuan University of Science and Engineering
Zhenyu Xing: Sichuan University
Zhiying Ding: Sichuan University
Qinlong Wen: Sichuan University
Zhigong Wei: Sichuan University
Xiaolin Wang: Macau University of Science and Technology
Mohsen Adeli: Free University of Berlin
Shuang Li: Sichuan University
Chong Cheng: Sichuan University
Xingchen Peng: Sichuan University

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract Designing efficient, biocompatible radiation-sensitive materials to activate systemic immune responses can maximize tumoricidal effects against malignant tumors. Here, inspired by natural Mn-peroxidase, we propose the de novo design of the RuMn-oxygen complex (MnBTC-Ru) for biocatalytic and radiosensitization therapies to eradicate primary and metastatic tumors. Our results reveal that Mn-organic ligands can enhance the electron density of Ru clusters, thereby optimizing their binding to oxygen species and resulting in high reactive oxygen species and oxygen generation. Accordingly, MnBTC-Ru with radiation can enhance cell membrane and DNA damage, triggering apoptosis though oxidative damage, heightening radiosensitization, and activating CD8+ T cells. When combined with anti-PD-1 therapy, this synergistic approach generates robust systemic antitumor responses in female mice, promoting the abscopal effect and establishing enduring immune memory against tumors, thereby reducing recurrence and metastasis. This design presents superior biocatalytic and radiosensitizing properties, which may provide promising and practical bio-nanotechnology for future treatments on eradicating primary and metastatic tumors.

Date: 2025
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DOI: 10.1038/s41467-025-62999-x

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