Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM

Jennifer E. Kung, Matthew C. Johnson, Dimitry Tegunov, Christine C. Jao, Ping Wu, Angela Oh, May Lin, Jose M. Daria, Christopher M. Koth, Christopher P. Arthur, Alexis Rohou and Jawahar Sudhamsu ()
Additional contact information
Jennifer E. Kung: Genentech Inc.
Matthew C. Johnson: Genentech Inc.
Dimitry Tegunov: Genentech Inc.
Christine C. Jao: Genentech Inc.
Ping Wu: Genentech Inc.
Angela Oh: Genentech Inc.
May Lin: Genentech Inc.
Jose M. Daria: Genentech Inc.
Christopher M. Koth: Genentech Inc.
Christopher P. Arthur: Genentech Inc.
Alexis Rohou: Genentech Inc.
Jawahar Sudhamsu: Genentech Inc.

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract High-resolution protein structures are essential for understanding biological mechanisms and drug discovery. While cryoEM has revolutionized structure determination of large protein complexes, most disease-related proteins are small (

Date: 2025
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DOI: 10.1038/s41467-025-63766-8

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