Bioadhesive and conformable bioelectronic interfaces for vasomotoricity monitoring and regulation

Xiner Wang, Weijian Fan, Yuxin Liu, Li Chen, Erda Zhou, Xiaoling Wei, Liuyang Sun, Bo Yu, Tiger H. Tao (), Zhitao Zhou () and Jinyun Tan ()
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Xiner Wang: Chinese Academy of Sciences
Weijian Fan: Huashan Hospital of Fudan University
Yuxin Liu: Chinese Academy of Sciences
Li Chen: Huashan Hospital of Fudan University
Erda Zhou: Chinese Academy of Sciences
Xiaoling Wei: University of Chinese Academy of Sciences
Liuyang Sun: Chinese Academy of Sciences
Bo Yu: Huashan Hospital of Fudan University
Tiger H. Tao: Neuroxess Co. Ltd
Zhitao Zhou: University of Chinese Academy of Sciences
Jinyun Tan: Huashan Hospital of Fudan University

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract The autonomic nervous system (ANS) dynamically regulates vasomotor function to maintain vascular homeostasis, yet current clinical tools lack the capacity to capture its electrophysiological basis, particularly following stent implantation. Herin, we report a bioadhesive and conformable bioelectronic (BACE) interface engineered for effective monitoring and modulation of vasomotoricity. Incorporating silk fibroin-based adhesives, the interface adheres robustly to cylindrical surfaces in aqueous conditions for up to two months. It exhibits low interfacial impedance (6.77 ± 2.13 kΩ at 1 kHz) and background noises (2.63 ± 0.52 μV) in vivo, enabling precise recording of varying vasomotor states. In a stent model, the interface identifies alterations in bioelectrical activity associated with vasomotor dysfunction, validated against ultrasound-derived arterial stiffness as clinical gold standards. Furthermore, we demonstrate a bidirectional system for the detection and modulation of dysfunction to restore vasomotor activity and elasticity. These findings provide insights into vasomotor electrophysiology mechanisms and underscore the therapeutic potential of bioelectronic modulation in vascular disease.

Date: 2025
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DOI: 10.1038/s41467-025-64118-2

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