Chronic kidney disease is associated with increased risk of sudden cardiac death

Yalan Li, Ruchao Jiang, Chenxi Ouyang, Jie Wang, Qingwei Yu, Jun Lu, Wei Hong, Shiqi Liu, Yan Chen, Jingjing Cai, Hong Yuan, Li Zhang () and Yao Lu ()
Additional contact information
Yalan Li: Central South University
Ruchao Jiang: Central South University
Chenxi Ouyang: Central South University
Jie Wang: Central South University
Qingwei Yu: Central South University
Jun Lu: Central South University
Wei Hong: Central South University
Shiqi Liu: Central South University
Yan Chen: Nanjing Medical University
Jingjing Cai: Central South University
Hong Yuan: Central South University
Li Zhang: Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Yao Lu: Central South University

Nature Communications, 2025, vol. 16, issue 1, 1-8

Abstract: Abstract Patients with chronic kidney disease (CKD) are recognized as a higher risk group for cardiovascular disease (CVD) due to various traditional risk factors, kidney-specific factors, and comorbidities, which have recently attracted significant attention. However, the long-term risk of acute CVD events such as sudden cardiac death (SCD) in CKD patients is unclear. Using the UK Biobank and Changsha cohorts, we find that CKD is associated with an increased risk of SCD. Patients with early-stage CKD, especially those with advanced CKD, faced an elevated risk of SCD. Furthermore, through proteomic analyses of the UK Biobank and Framingham Offspring Cohort, we identify five candidate proteins (NTproBNP, ANGPT2, FGF23, DTNB, and SEPTIN8) linked to SCD risk in CKD patients. Here, we show that patients with CKD have an increased risk of SCD in the long term, underscoring the imperative for strategies that address both cardiovascular risk and renal function in this population.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-64254-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64254-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-64254-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().