Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci

Cindy Im (), Andrew R. Raduski, Lauren J. Mills, Kashi Raj Bhattarai, Robert J. Mobley, Kelly R. Barnett, Zhanni Lu, Kenneth Liao, Nathan Anderson, Rebecca A. Johnson, Erica Langer, Anthony J. Hooten, Alix E. Seif, Kathrin M. Bernt, Matthew Tsang, Brandon A. Mamou, Luis Gil- de-Gómez, Julie A. Wolfson, Danielle N. Friedman, Neerav Shukla, Laura J. Klesse, Erin L. Marcotte, Lingyun Ji, Alice Dang, Minjie Luo, Yiming Zhong, Jalen Langie, Charleston W. K. Chiang, Adam Smith, Joseph L. Wiemels, Andrew DeWan, Xiaomei Ma, Catherine Metayer, Zhaoming Wang, Heather H. Nelson, Nathan Pankratz, Tianzhong Yang, Saonli Basu, Lucie M. Turcotte, Jun J. Yang, Daniel Savic, Michael E. Scheurer and Logan G. Spector ()
Additional contact information
Cindy Im: University of Minnesota
Andrew R. Raduski: University of Minnesota
Lauren J. Mills: University of Minnesota
Kashi Raj Bhattarai: St. Jude Children’s Research Hospital
Robert J. Mobley: St. Jude Children’s Research Hospital
Kelly R. Barnett: St. Jude Children’s Research Hospital
Zhanni Lu: University of Minnesota
Kenneth Liao: University of Minnesota
Nathan Anderson: University of Minnesota
Rebecca A. Johnson: University of Minnesota
Erica Langer: University of Minnesota
Anthony J. Hooten: University of Minnesota
Alix E. Seif: Children’s Hospital of Philadelphia
Kathrin M. Bernt: Children’s Hospital of Philadelphia
Matthew Tsang: Children’s Hospital of Philadelphia
Brandon A. Mamou: Children’s Hospital of Philadelphia
Luis Gil- de-Gómez: University of Cantabria-IDIVAL
Julie A. Wolfson: University of Alabama at Birmingham
Danielle N. Friedman: Memorial Sloan Kettering Cancer Center
Neerav Shukla: Memorial Sloan Kettering Cancer Center
Laura J. Klesse: University of Texas Southwestern Medical School
Erin L. Marcotte: University of Minnesota
Lingyun Ji: University of Southern California
Alice Dang: Children’s Oncology Group
Minjie Luo: Children’s Hospital of Philadelphia
Yiming Zhong: Children’s Hospital of Philadelphia
Jalen Langie: University of Southern California Keck School of Medicine
Charleston W. K. Chiang: University of Southern California Keck School of Medicine
Adam Smith: University of Southern California Keck School of Medicine
Joseph L. Wiemels: University of Southern California Keck School of Medicine
Andrew DeWan: Yale School of Public Health
Xiaomei Ma: Yale School of Public Health
Catherine Metayer: University of California
Zhaoming Wang: St. Jude Children’s Research Hospital
Heather H. Nelson: University of Minnesota
Nathan Pankratz: University of Minnesota
Tianzhong Yang: University of Minnesota
Saonli Basu: University of Minnesota
Lucie M. Turcotte: University of Minnesota
Jun J. Yang: St. Jude Children’s Research Hospital
Daniel Savic: St. Jude Children’s Research Hospital
Michael E. Scheurer: Baylor College of Medicine
Logan G. Spector: University of Minnesota

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy. Given racial/ethnic differences in incidence and outcomes, B-ALL genome-wide association studies among children of African ancestry are needed. Leveraging multi-institutional datasets with 840 African American children with B-ALL and 3360 controls, nine loci achieved genome-wide significance (P

Date: 2025
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DOI: 10.1038/s41467-025-64337-7

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