Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration

Jonathan R. Clark (), D. S. Abdullah Al Maruf, Eva Tomaskovic-Crook, Kai Cheng, William T. Lewin, Hai Xin, Boyang Wan, Jiongyu Ren, Chi Wu, Hedi V. Kruse, Daniel K. Lawrence, Innes Wise, Aditi Gupta, Maria A. Woodruff, Maryam Alsadat Rad, David Leinkram, Timothy Manzie, Krishnan Parthasarthi, James Wykes, Tsu-Hui Hubert Low, Dale Howes, Catriona Froggatt, Ruta Gupta, Gordon Wallace, Qing Li, David R. McKenzie and Jeremy M. Crook ()
Additional contact information
Jonathan R. Clark: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
D. S. Abdullah Al Maruf: Chris O’Brien Lifehouse
Eva Tomaskovic-Crook: Chris O’Brien Lifehouse
Kai Cheng: Chris O’Brien Lifehouse
William T. Lewin: Chris O’Brien Lifehouse
Hai Xin: Chris O’Brien Lifehouse
Boyang Wan: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
Jiongyu Ren: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
Chi Wu: The University of Sydney
Hedi V. Kruse: Chris O’Brien Lifehouse
Daniel K. Lawrence: The University of Wollongong
Innes Wise: The University of Sydney
Aditi Gupta: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
Maria A. Woodruff: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
Maryam Alsadat Rad: Chris O’Brien Lifehouse
David Leinkram: Chris O’Brien Lifehouse
Timothy Manzie: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
Krishnan Parthasarthi: Chris O’Brien Lifehouse
James Wykes: Chris O’Brien Lifehouse
Tsu-Hui Hubert Low: Chris O’Brien Lifehouse
Dale Howes: Chris O’Brien Lifehouse
Catriona Froggatt: Chris O’Brien Lifehouse
Ruta Gupta: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
Gordon Wallace: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
Qing Li: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer
David R. McKenzie: Chris O’Brien Lifehouse
Jeremy M. Crook: NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer

Nature Communications, 2025, vol. 16, issue 1, 1-20

Abstract: Abstract Scaffold-guided bone regeneration is poised to revolutionize the management of critical-sized bone defects. However, translation into clinical practice has been hampered by the focus on bioresorbable scaffolds where the rate of degradation needs to match the rate of bone formation and metal plates are required to overcome their mechanical limitations. Metal plates are problematic because they cause stress shielding and X-ray perturbation, increasing the likelihood of hardware failure and interfering with post-operative radiotherapy and imaging. Segmental defects of the mandible are challenging due to high tensile and shear stresses encountered during mastication, with the ovine mandible especially vexing because of the high repetitive loads. Here we show long-term reconstruction of ovine segmental mandibulectomy defects using a permanent, patient-matched, numerically optimized, 3D-printed, thermally toughened, plasma-treated, and laser-sintered polyetherketone gyroid scaffold housing a resorbable ceramic lattice infused with a stem cell laden hydrogel serving as an osteoinductive reservoir of calcium. The durable clinical performance observed indicates a translatable alternative to traditional reconstruction using bone grafts with metal plate fixation.

Date: 2025
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DOI: 10.1038/s41467-025-64466-z

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