Considerations and perspectives on phage therapy from the transatlantic taskforce on antimicrobial resistance

Kyung Moon (), Carmen Coxon (), Christine Årdal, Radu Botgros, Sarah Djebara, Laura Durno, Cara R. Fiore, Jean-Baptiste Perrin (), Dennis M. Dixon and Marco Cavaleri
Additional contact information
Kyung Moon: National Institutes of Health, National Institute of Allergy and Infectious Diseases
Carmen Coxon: South Mimms, MHRA Science Campus, Blanche Lane
Christine Årdal: Norwegian Institute of Public Health
Radu Botgros: European Medicines Agency, Public Health Threats Department
Sarah Djebara: Queen Astrid military hospital, Center for Infectious diseases ID4C
Laura Durno: Health Canada, Health Products and Food Branch
Cara R. Fiore: the U S Food and Drug Administration (US FDA), Center for Biologics Evaluation and Research
Jean-Baptiste Perrin: Health emergency preparedness and response authority (HERA), European Commission
Dennis M. Dixon: National Institutes of Health, National Institute of Allergy and Infectious Diseases
Marco Cavaleri: European Medicines Agency, Public Health Threats Department

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract Amid rising antimicrobial resistance and limited antibiotic innovation, bacteriophages are gaining attention as potential therapeutics across human health, animal, and food sectors. Despite historical use, their clinical application in humans remains constrained by scientific, industrial, and regulatory challenges. To address these issues, the Transatlantic Task Force on Antimicrobial Resistance (TATFAR) convened sessions with experts from member parties. This perspective synthesizes insights from the TATFAR group, highlighting regulatory differences, research gaps, and opportunities for international collaborations to advance bacteriophage therapy.

Date: 2025
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DOI: 10.1038/s41467-025-64608-3

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